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Teach patients and caregivers on how to recognize respiratory depression and emphasize the necessity of calling 911 or having emergency healthcare support instantly during the event of the known or suspected overdose (see WARNINGS, Everyday living-Threatening Respiratory Despair).
Lengthy-time period research To guage the carcinogenic probable of the combination of codeine and acetaminophen have not been performed.
Propulsive peristaltic waves within the colon are decreased, although tone may very well be elevated to The purpose of spasm, causing constipation. Other opioid-induced effects may well involve a discount in biliary and pancreatic secretions, spasm of sphincter of Oddi, and transient elevations in serum amylase.
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biliary spasm (producing discomfort in the best side of one's abdomen, specifically right after taking in a meal, which may unfold to your right shoulder)
Acetaminophen and codeine phosphate tablets are indicated for that management of delicate to reasonable agony, where treatment method having an opioid is suitable and for which different treatment options are inadequate.
Neonatal Opioid Withdrawal Syndrome Inform woman sufferers of reproductive opportunity that utilization of acetaminophen and codeine phosphate tablets for an prolonged time period for the duration of pregnancy may result in neonatal opioid withdrawal syndrome, which may be existence-threatening if not recognized and treated (see Safety measures, Pregnancy).
Get emergency assist or connect with 911 right away if you're taking too many acetaminophen and codeine phosphate tablets (overdose). Any time you initially start off using acetaminophen and codeine phosphate tablets, Whenever your dose is adjusted, or if you are taking too much (overdose), really serious or lifestyle-threatening respiration difficulties that can cause Demise may manifest.
Wean the affected person off of the opioid to allow adrenal perform to Get better and continue corticosteroid treatment method right until adrenal function recovers. Other opioids may very well be attempted as some cases claimed utilization of a distinct opioid with out recurrence of adrenal insufficiency. The information offered does not recognize any particular opioids as getting far more prone to be connected with adrenal insufficiency.
Warn people to not travel or function risky equipment Unless of course These are tolerant to the effects of acetaminophen and codeine phosphate tablets and know the way they'll react to the medication (see Safeguards, Info for Sufferers/Caregivers).
Two-year carcinogenicity studies have been executed in F344/N rats and B6C3F1 mice. There was no proof of carcinogenicity in male and woman rats, respectively, at dietary doses nearly 70 and eighty mg/kg/working day of codeine sulfate (somewhere around 2 periods the maximum encouraged daily dose of 360 mg/day for Grown ups on the mg/m2 foundation) for 2 yrs.
Hyperalgesia and Allodynia: Situations of hyperalgesia and allodynia are already described with opioid therapy of any length (see WARNINGS).
Reserve concomitant prescribing of acetaminophen and codeine phosphate tablets and benzodiazepines or other CNS depressants to be used in people for whom substitute treatment method selections are inadequate (see Safety measures, Drug read more Interactions).
It may be an offence to push If the capability to push securely is impacted. There's further facts for sufferers who will be meaning to drive in Good Britain - head to -driving-regulation